Publications

Selected Publications

Hirata S, Li W, Defranoux N, Cavet G, Bolce R, Yamaoka K, Saito K, Tanaka Y. A multi-biomarker disease activity score tracks clinical response consistently in patients with rheumatoid arthritis treated with different anti-tumor necrosis factor therapies: A retrospective observational study. Modern Rheumatology 2014. doi:10.3109/14397595.2014.958893

Hambardzumyan K, Bolce R, Saevarsdottir S, Cruickshank SE, Sasso EH, Chernoff D, Forslind K, Petersson I, Geborek P, van Vollenhoven RF. Pre-treatment multi-biomarker disease activity score and radiographic progression in early RA: results from the SWEFOT trial. Ann Rheum Dis 2014. doi:10.1136/annrheumdis-2013-204986

van der Helm-van Mil AHM, Knevel R, Cavet G, Huizinga TWJ, and Haney DJ. An Evaluation of Molecular and Clinical Remission in Rheumatoid Arthritis by Assessing Radiographic Progression. Rheumatology (Oxford). 2013. doi:10.1093/rheumatology/kes378.

Segurado O, Sasso E. Vectra DA for the objective measurement of disease activity in patients with rheumatoid arthritis. Clin Exp Rheumatol 2014; 32 (Suppl. 85): S29-S34.

Markusse IM, Dirven L, van den Broek M, Bijkerk C, Huub Han K, Karel Ronday H, Bolce R, Sasso EH, Kerstens PJSM, Lems WF, Huizinga TWJ, Allaart CF. A Multibiomarker Disease Activity Score for Rheumatoid Arthritis Predicts Radiographic Joint Damage in the BeSt Study. The Journal of Rheumatology131412. doi:10.3899/jrheum.131412

Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga TWJ, Allaart CF. A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study. Rheumatology (Oxford) 2013, doi: 10.1093/rheumatology/kes362.

Curtis JR, van der Helm-van Mil AH, Knevel R, Huizinga TW, Haney DJ, Shen Y, Ramanujan S, Cavet G, Centola M, Hesterberg LK, Chernoff D, Ford K, Shadick NA, Hamburger M, Fleischmann R, Keystone E, Weinblatt ME. Validation of a novel multi-biomarker test to assess rheumatoid arthritis disease activity. Arthritis Care & Research. 2012; 64 (12):1794–1803.

Li W, Sasso E, Emerling D, Cavet G, Ford K. Impact of a multi-biomarker disease activity test on rheumatoid arthritis treatment decisions and therapy use. Current Medical Research & Opinion. 2013; 29(1): 85-92.

Michaud K, Strand V, Shadick N, Degtiar I, Ford K, Michalopoulos S, Hornberger J. Outcomes and costs of incorporating a multibiomarker disease activity test in the management of patients with rheumatoid arthritis. Rheumatology (Oxford) 2015, doi:10.1093/rheumatology/kev023.

Bakker MF, Cavet G, Jacobs JWG, Bijlsma JWJ, Haney D, Shen Y, Hesterberg L, Smith D, Centola M, van Roon JAG, Lafeber FPJG, Welsing PMJ. Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study. Ann Rheum Dis. 2012; doi:10.1136/annrheumdis-2011-200963

Burmester G, Weinblatt ME, McInnes IB, Porter D, Barbarash O, Vatutin M, et al. Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis. Ann Rheum Dis. 2012; doi:10.1136/annrheumdis-2012-202450.

Centola M, Cavet G, Shen Y, Ramanujan S, Knowlton N, Swan K, Turner M, Sutton C, Smith D, Haney D, Chernoff D, Hesterberg L, Carulli J, Taylor P, Shadick N, Weinblatt M, Curtis J. Development of a Multi-Biomarker Disease Activity Test for Rheumatoid Arthritis. PLOS ONE 2013 Apr 9;8(4):e60635. doi:10.1371/journal.pone.0060635.

Eastman PS, Manning WC, Qureshi F, Haney D, Cavet G, Alexander C, Hesterberg LK. Characterization of a multiplex, 12-biomarker test for rheumatoid arthritis. Journal of Pharmaceutical and Biomedical Analysis, epub, June 5, 2012.

Zhao X, Qureshi F, Eastman PS, Manning W, Alexander C, Robinson W, Hesterberg L. Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis. Journal of Immunological Methods. 2012; 378: 72-80

Peabody JW, Strand V, Shimkhada R, Lee R, Chernoff D. Impact of Rheumatoid Arthritis Disease Activity Test on Clinical Practice. PLoS ONE 2013 (8)5: e63215

 

Selected Presentations

Additional Crescendo Bioscience research and publications can be found at www.crescendobio.com.

Sasso E, Wu G, Hwang C, Weinblatt M, Shadick N, Alexander C, Segurado O. The Multi-Biomarker Disease Activity Score as a Predictor of Radiographic Progression in a Registry of Patients with Rheumatoid Arthritis. Arthritis Rheum 2014;66 Suppl 11 :1299.

Ma M, Garrood T, Li W, Defranoux N, Kingsley G, Cope A, Scott D. Multi-Biomarker Disease Activity Score is Associated with Power Doppler Ultrasound in Patients with Rheumatoid Arthritis in Low Disease Activity State. Arthritis Rheum 2014;66 Suppl 11 :1300.

Hambardzumyan K, Bolce R, Saevarsdottir S, Forslind K, Petersson I, Geborek P, Sasso E, Chernoff D, Cruickshank S, van Vollenhoven R. In Early Rheumatoid Arthritis, the Multi-Biomarker Disease Activity Score at Different Time-Points is Predictive of Subsequent Radiographic Progression. Arthritis Rheum 2014;66 Suppl 11 :153.

Hambardzumyan K, Bolce R, Saevarsdottir S, Forslind K, Petersson I, Geborek P, Sasso E, Chernoff D, Cruickshank S, van Vollenhoven R. In Early Rheumatoid Arthritis Patients with Non-Response to Methotrexate Monotherapy the Change in Multi-Biomarker Disease Activity Score is Differentially Associated with Subsequent Response to Non-Biological Versus Biological Therapy. Arthritis Rheum 2014;66 Suppl 11 :155.

van Vollenhoven R, Bolce R, Hambardzumyan K, Saevarsdottir S, Forslind K, Petersson I, Sasso E, Hwang C, Segurado O, Geborek P. Using the Multi-Biomarker Disease Activity Score as a Complementary Inclusion Criterion for Clinical Trials in Rheumatoid Arthritis May Enhance Recruitment. Arthritis Rheum 2014;66 Suppl 11 :159.

Schett G, Finzel S, Rech J, Sasso EH, Segurado OG. Residual Inflammatory Activity Assessed by a Multi-Biomarker Disease Activity Blood Test is Linked to Structural Damage in RA Patients in Low Disease Activity/Remission and Normal C-Reactive Protein Level. EULAR Congress 2014. Ann Rheum Dis 2014;73(Suppl2).

Hambardzumyan K, Bolce R, Saevarsdottir S, Forslind K, Petersson IF, Geborek P, Ernestam S, Sasso EH, Chernoff D, Cruickshank SE, van Vollenhoven RF. In Early RA Patients With Non-Response to Methotrexate Monotherapy the Change in Multi-Biomarker Disease Activity Score is Differentially Associated With Subsequent Response to Non-Biological Versus Biological Therapy.  EULAR Congress 2014. Ann Rheum Dis 2014;73(Suppl2).

Krabbe S, Bolce RJ, Brahe CH, Døhn UM, Wu G, Ejbjerg BJ, Hetland ML, Sasso EH, Chernoff D, Hansen MS, Knudsen L, Hansen A, Madsen OR, Hasselquist M, Møller JM, Østergaard M. Validation of a Multi-Biomarker Disease Activity Score in Rheumatoid Arthritis in Relation to Imaging Inflammation and Damage. EULAR Congress 2014. Ann Rheum Dis 2014;73(Suppl2).

Yamaoka K, Kubo S, Li W, Sonomoto K, Hirata S, Sasso EH, Saito K, Defranoux NA, Tanaka Y. Effects of Tofacitinib Treatment on Leptin and Other Components of the Multi-Biomarker Disease Activity Score in Patients With Rheumatoid Arthritis. EULAR Congress 2014. Ann Rheum Dis 2014;73(Suppl2).

Hambardzumyan K, Bolce R, Saevarsdottir S, Forslind K, Petersson IF, Geborek P, Ernestam S, Sasso EH, Chernoff D, Cruickshank SE, van Vollenhoven RF.  In Early RA, The Multi-Biomarker Disease Activity Score at Different Time-Points is Predictive of Subsequent Radiographic Progression. EULAR Congress 2014. Ann Rheum Dis 2014;73(Suppl2).

Ma MH, Garrood T, Li W, Defranoux N, Kingsley GH, Scott DL, Cope AP.  Multi-Biomarker Disease Activity (Vectra® DA Algorithm) Score is Associated With Power Doppler Ultrasound in Patients With Rheumatoid Arthritis in Low Disease Activity State: The Remira Cohort.  EULAR Congress 2014. Ann Rheum Dis 2014;73(Suppl2).

van Vollenhoven RF, Bolce R, Hambardzumyan K, Saevarsdottir S, Forslind K, Ernestam S, Petersson IF, Sasso EH, Hwang CC, Segurado OG, Geborek P.  Using the Multi-Biomarker Disease Activity Score as a Complementary Inclusion Criterion for Clinical Trials in Rheumatoid Arthritis May Enhance Recruitment. EULAR Congress 2014. Ann Rheum Dis 2014;73(Suppl2).

Li, W, Haney, DJ, Cavet, G, Huizinga, TW, Sasso, EH, van der Helm-van Mil, AHM; The Multi-Biomarker Disease Activity Test (Vectra® DA) Estimates Risk Of Radiographic Progression For Patients With Rheumatoid Arthritis From The Leiden Early Arthritis Clinic. Arthritis Rheum 2013;65 Suppl 10 :1788 DOI: 10.1002/art.2013.65.issue-s10

Hambardzumyan, K, Saevarsdottir, S, Bolce, R, Forslind, K, Ernestam, S, Petersson, IF, et al; In Early Rheumatoid Arthritis, The 12 Individual Biomarkers That Comprise The Multiple Biomarker Disease Activity Score Relate Differentially To Clinical Response and Radiographic Progression: Results From a Randomized Trial. Arthritis Rheum 2013;65 Suppl 10 :1789 DOI: 10.1002/art.2013.65.issue-s10

Lee, YC, Hackett, J, Alexander, C, Frits, MA, Iannaccone, CK, Shadick, NA, et al; Application Of a Multi-Biomarker Disease Activity (Vectra® DA) Score For Assessing Rheumatoid Arthritis Patients With Fibromyalgia Or Low C-Reactive Protein. Arthritis Rheum 2013;65 Suppl 10 :2683 DOI: 10.1002/art.2013.65.issue-s10

Hambardzumyan, K, Bolce, R, Cruickshank, SE, Sasso, EH, Chernoff, D, Forslind, K, et al; A Multi-Biomarker Disease Activity Score Correlates With Radiographic Progression In Early Rheumatoid Arthritis: Results From a Randomized Trial. Arthritis Rheum 2013;65 Suppl 10 :1312 DOI: 10.1002/art.2013.65.issue-s10

Hensvold, AH, Joshua, V, Saevarsdottir, S, Larkin, M, Israelsson, L, Qureshi, F, et al; Autoantibodies To Citrullinated Proteins Associate With Bone Destruction Marker and Are Modulated By First Anti Rheumatic Treatment In Early Rheumatoid Arthritis. Arthritis Rheum 2013;65 Suppl 10 :1327 DOI: 10.1002/art.2013.65.issue-s10

Krabbe, S, Bolce, RJ, Brahe, CH, Døhn, UM, Cruickshank, S, Ejbjerg, BJ, et al; Early Changes In a Multi-Biomarker Disease Activity Score After Starting Adalimumab Treatment Predict Change In MRI Inflammation At 6 Months. Arthritis Rheum 2013;65 Suppl 10 :1436 DOI: 10.1002/art.2013.65.issue-s10

Hirata, S, Li, W, Defranoux, NA, Bolce, R, Sasso, EH, Kubo, S, et al; Repeated High Or Low Multi-Biomarker Disease Activity (VECTRA® DA Algorithm) Scores Associated With Radiographic Outcomes In Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors. Arthritis Rheum 2013;65 Suppl 10 :1453 DOI: 10.1002/art.2013.65.issue-s10

Hambardzumyan K, Saevarsdottir S, Bolce R, Forslind K, Ernestam S, Petersson I, Geborek P, Chernoff D, Haney D, Sasso EH, van Vollenhoven RF. Multi-Biomarker Disease Activity (MBDA) Score and the 12 Individual Biomarkers in Early Rheumatoid Arthritis Patients Relate Differentially to Clinical Response and Radiographic Progression: Results from the SWEFOT Trial. Poster FRI0061. EULAR Congress 2013

Maijer KI, de Hair MJH, Li W, Defranoux NA, Sasso EH, Gerlag DM, Tak PP. Evaluation of a Multi-Biomarker Disease Activity (Vectra® DA Algorithm) in Early Rheumatoid Arthritis and Unclassified Arthritis Patients. Poster FRI0062. EULAR Congress 2013

Hanami K, Hirata S, Tasaka H, Li W, Bolce R, Sasso EH, Defranoux NA, Yamaoka K, Saito K, Tanaka Y. Behavior of the Multi-Biomarker Disease Activity (Vectra® DA Algorithm) Score and Components in Patients with Rheumatoid Arthritis Treated with Tocilizumab. Poster FRI0066. EULAR Congress 2013

Ma MH, Li W, Defranoux N, Kingsley, GH, Scott DL, Cope, AP. A Multi-Biomarker Disease Activity (Vectra® DA Algorithm)Score and Components Are Associated with Sustained Clinical Remission in Rheumatoid Arthritis: the REMIRA Study; Poster FRI0075. EULAR Congress 2013

Jurgens MS, Bijlsma JW, Jacobs JW, Bakker MF, Lafeber FP, Welsing PM, Cavet G, Chernoff DN, Sasso EH, Li W, Haney DJ. Response to MTX Plus Prednisone in CAMERA II Using a Multi-Biomarker Disease Activity Test (Vectra® DA) and DAS28-ESR. Poster FRI0079. EULAR Congress 2013

Li W, van der Helm-van Mil A, Knevel R, Cavet G, Huizinga T, Haney D. Biomarker-Based Estimates of Risk of Radiographic Progression in the Leiden Early Arthritis Cohort. Poster FRI0098. EULAR Congress 2013

Hirata S, Li W, Defranoux NA, Bolce R, Haney DJ, Sasso EH, Kubo S, Fukuyo S, Mizuno Y, Yamaoka K, Saito K, Tanaka Y. A Multi-Biomarker Disease Activity (Vectra® DA Algorithm) Score is Associated with Radiographic Outcomes in RA Patients Treated with TNF Inhibitors. Poster SAT0012. EULAR Congress 2013

Li W, Hensvold AH, Saevarsdottir S, Defranoux NA, Klareskog L, Catrina AI. Characterization of the Multi-Biomarker Disease Activity (Vectra® DA Algorithm) Score in a Subgroup of Patients from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) Cohort Receiving Methotrexate. Poster SAT0033. EULAR Congress 2013

Lee YC, Haney D, Alexander C, Frits ML, Iannacconne CK, Shadick NA, Segurado OG, Weinblatt ME, Sasso EH. Application of a Multi-Biomarker Disease Activity (Vectra® DA) Score for Assessing Rheumatoid Arthritis Patients with Low CRP or Fibromyalgia. Poster SAT0099. EULAR Congress 2013

Haney DJ, Cavet G, Durez P, Alten R, Burmester GR, Tak PP, Catrina AI, Gaillez C, Bars ML, Connolly S, Townsend R. Correlation of a Multi-Biomarker Disease Activity Response Assessment to Disease Activity Score 28 (C-Reactive Protein) Response Assessment and OMERACT RAMRIS Scores in a Placebo-Controlled Rheumatoid Arthritis Clinical Trial with Abatacept (ASSET). Poster 2159. ACR 2012 Annual Scientific Meeting, Washington DC.

Biljsma JWJ, Verhoef-Jurgens M, Bakker M, Jacobs JWG, Lafeber FPJ, Welsing PMJ, Cavet G, Chernoff D, Li W, Sasso EH, Haney DJ. Response to Methotrexate Plus Prednisone in CAMERA II Using a Multi-Biomarker Disease Activity (Vectra™ DA) Test and DAS28ESR. Poster 2125. ACR 2012 Annual Scientific Meeting, Washington DC.

Tanaka Y, Hanami K, Tasaka H, Fukuyo S, Haney DJ, Bolce R, Debranoux N, Cavet G, Chernoff D, Yamaoka K, Saito K, Hirata S. A Multi-Biomarker Disease Activity Score (Vectra™ DA algorithm score) Reflects Clinical Disease Activity and Structural Changes in Rheumatoid Arthritis Patients Treated with Tocilizumab. Poster 2121. ACR 2012 Annual Scientific Meeting, Washington DC.

Yamaoka K, Kubo S, Sonomoto K, Hirata S, Cavet G, Bolce R, Rowe M, Chernoff D, Defranoux N, Saito K, Tanaka Y. Correlation of a Multi-Biomarker Disease Activity (Vectra ™ DA) Score with Clinical Disease Activity And Its Components with Radiographic Progression in Rheumatoid Arthritis Patients Treated with Tofacitinib. Poster 2162. ACR 2012 Annual Scientific Meeting, Washington DC.

Hensvold AH, Saevarsdottir S, Li W, Lundberg K, Malmstrom V, Cavet G, Defranoux N, Klareskog L, Catrina AI. Studies of Disease and Therapy-Response Biomarkers in Early Rheumatoid Arthritis Treated with Methotrexate. Poster 2130. ACR 2012 Annual Scientific Meeting, Washington DC.

Lamberth S, Cherkas Y, Brodmerkel C, Currran M. Utility of Vectra™ DA on Assessment of Rheumatoid Arthritis Disease Activity and Golimumab Response: Results of a Pilot Study From a Phase 3 Trial in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy. Poster 2165. ACR 2012 Annual Scientific Meeting, Washington DC.

Yamaoka K, Kubo S, Sonomoto K, Hirata S, Voinov A, Rowe M, Cavet G, Saito K, Tanaka Y. A Multi-Biomarker Disease Activity Score (MBDA) Score Measures Rheumatoid Arthritis Disease Activity in Patients Treated with the JAK Inhibitor Tofacitinib. Poster THU0145. EULAR Congress 2012.

Ma MH, Ramanujan S, Cavet G, Haney DJ, Zhao X, Eastman PS, Kingsley GH, Scott DL and Cope AP. Investigation of a Multi-Biomarker Disease Activity (Vectra DA) Signature and Algorithm Score in Rheumatoid Arthritis Patients with Low Disease Activity: The REMIRA Study. Poster 361. ACR 2011 Annual Scientific Meeting, Chicago, IL.

Weinblatt ME, Shadick NA, Manning W, Coblyn JS, Centola M, Chernoff D, Cavet G, Haney DJ. Use of a Multi-Biomarker Score for Rheumatoid Arthritis Disease Activity (Vectra™ DA) to Assess Response to Therapy. (Poster Session I: May 26, 2011, 11:45 BST). EULAR Congress 2011.

Ma MH, Ramanujan S, Haney DJ, Cavet G, Kingsley GH, Scott DL, Cope AP. Biomarker Signatures in Rheumatoid Arthritis Patients with Low Disease Activity: The REMIRA Study. (Poster Session III: May 28, 2011, 10:15 BST). EULAR Congress 2011.

Fleischmann R, Curtis JR, Hamburger M, Blumstein H, Swan K, Cavet G, Chernoff D on behalf of the InFoRM Study Group. RA Population Characteristics in InFoRM: a Longitudinal Observational Study. Poster # SAT0518. EULAR Congress 2010.